Severe traumatic brain injury (TBI) modulates the kinetic profile of the inflammatory response of markers for neuronal damage

The inflammatory response plays an important role in the pathophysiology of multiple injuries. This study examines the effects of severe trauma and inflammatory response on markers of neuronal damage. A retrospective ana
The inflammatory response plays an important role in the pathophysiology of multiple injuries. This study examines the effects of severe trauma and inflammatory response on markers of neuronal damage. A retrospective analysis of prospectively collected data in 445 trauma patients (Injury Severity Score (ISS) ≥ 16) is provided. Levels of neuronal biomarkers (calcium-binding Protein B (S100b), Enolase2 (NSE), glial fibrillary acidic protein (GFAP)) and Interleukins (IL-6, IL-10) in severely injured patients (with polytrauma (PT)) without traumatic brain injury (TBI) or with severe TBI (PT+TBI) and patients with isolated TBI (isTBI) were measured upon arrival until day 5. S100b, NSE, GFAP levels showed a time-dependent decrease in all cohorts. Their expression was higher after multiple injuries (p = 0.038) comparing isTBI. Positive correlation of marker level after concomitant TBI and isTBI (p = 0.001) was noted, while marker expression after PT appears to be independent. Highest levels of IL-6 and -10 were associated to PT und lowest to isTBI (p < 0.001). In all groups pro-inflammatory response (IL-6/-10 ratio) peaked on day 2 and at a lower level on day 4. Severe TBI modulates kinetic profile of inflammatory response by reducing interleukin expression following trauma. Potential markers for neuronal damage have a limited diagnostic value after severe trauma because undifferentiated increase.
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Metadaten
Author:Cora Rebecca Schindler, Thomas Lustenberger, Mathias Woschek, Philipp Störmann, Dirk Henrich, Peter Radermacher, Ingo Marzi
URN:urn:nbn:de:hebis:30:3-555762
DOI:http://dx.doi.org/10.3390/jcm9061667
ISSN:2077-0383
Parent Title (English):Journal of Clinical Medicine
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2020/06/01
Date of first Publication:2020/06/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/09/23
Tag:GFAP; IL-10; IL-6; NSE; S100b; biomarker; multiple trauma; posttraumatic inflammation; risk prediction; traumatic brain injury (TBI)
Volume:9
Issue:(6), article 1667
Pagenumber:13
HeBIS PPN:470773847
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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