Mesenchymal stromal cells for osteonecrosis

  • Osteonecrosis (ON) is an acquired debilitating skeletal disorder, which is caused by a multitude of traumatic and non-traumatic etiological factors. Vascular damage, mechanical stress and increased intraosseous pressure have been discussed as contributors to ON. The optimal treatment of ON remains to be determined, since the current gold standard, core decompression, is insufficiently effective. Specific properties of mesenchymal stromal cells (MSCs) provide the rationale for their assessment in advanced stages of ON: Osteoinductive potential has been demonstrated and MSC preparations of suitable quality for use as medicinal products have been developed. Here we review the scant information on the use of allogeneic or autologous MSCs in advanced ON as well as potentially supportive data from pre-clinical studies with autologous bone marrow mononuclear cells (auto BM-MNCs), which have been studied quite extensively and the presumed therapeutic effect of which was attributed to the rare MSCs contained in these cell products. Outcomes in clinical trials with MSCs and auto-BM-MNCs remain preliminary and non-definitive, at best promising, with respect to their pharmacological effect. Clearly, though, the application of any of these cell therapies was technically feasible and safe in that it was associated with low complication rates. The heterogeneity of cell type and source, study protocols, cell manufacturing, cell properties, cell doses and surgical techniques might contribute to inconsistent results.

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Author:Sümmeyye Elgaz, Halvard-Björn BönigORCiDGND, Peter BaderORCiDGND
URN:urn:nbn:de:hebis:30:3-558836
DOI:https://doi.org/10.1186/s12967-020-02565-9
ISSN:1479-5876
Parent Title (German):Journal of translational medicine
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Language:English
Date of Publication (online):2020/10/20
Date of first Publication:2020/10/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/10/30
Tag:Cell-based therapies; Mesenchymal stromal cells (MSC); Osteonecrosis
Volume:18
Issue:Article number: 399
Page Number:10
HeBIS-PPN:472979981
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0