Open Access

Deniel Pesic, Ivan Srejovic, Djordje Stefanovic, Dusica Djordjevic, Dejan Cubrilo, Vladimir Zivkovic

• Production of free radicals and oxidative damage during physical activity is a topic that is intensively studied and paid a lot of attention, first of all in professional sports. Marathon is categorized as extremely demanding sports discipline, as it induces high energy consumption and also requires special mental self-control. We presented cases of two athletes of different age, who have been on dissimilar level of sports readiness, and also had various approach to physical activity and exercise. During 10 days they ran out 10 marathons, partly on a flat terrain, and partly on hilly, which produced different level of effort in conquering the terrain. Also, both athletes had complex supplementation scheme in order to prevent electrolyte imbalance and excessive production of free radicals. Blood samples were taken in the morning and immediately after the end of the marathon. Measured oxidative stress biomarkers changed without a noticeable pattern, but these changes did not vary greatly among themselves. Catalase activity in both marathon runners was higher after marathon almost after every race for 10 days. On the other hand, amount of reduced glutathione was lower after marathon in both athletes in the same manner. Based on the obtained results we can conclude that adequate supplementation could have crucial role in prevention of oxidative damage.
• Stvaranje slobodnih radikala i oksidaciono oštećenje je tema kojoj se posvećuje dosta pažnje i koja se intenzivno istražuje, pre svega kod profesionalnih sportista. Maraton se svrstava u izuzetno zahtevne sportske discipline koja podrazumeva veliku energetsku potrošnju i specifičnu mental-nu samokontrolu. Prikazali smo slučaj dvojice maratonaca različite starosne dobi, različite fizičke spremnosti i sa različitim prisupom fizičkoj aktivnosti i vežbanju. Tokom 10 dana istrčali su 10 maratona, delom na ravnom, a delom na brdovitom terenu, što je uzrokovalo različito opterećenje tokom savladavanja pojedinih deonica. Takođe, trkači su imali kompleksnu shemu suplementacije u cilju prevencije elektrolitnog disbalansa i prekomerne produkcije slobodnih radikala. Uzorci krvi su uzimani ujutru i odmah nakon završetka maratona. Promne vrednosti merenih biomarkera oksidacionog stresa nisu imale bilo kakav obrazac, ali ove promene nisu značajno varirale između maratonaca. Aktivnost katalaze kod oba maratonca je bila znatno viša nakon maratona gotovo tokom svih 10 dana. Sa druge strane, količina redukovanog glutationa je bila niža nakon maraton kod oba trkača. Na osnovu dobijenih rezultata može da se zaključi da adekvatna suplementacija može da ima presudnu ulogu u prevenciji oksidacionog oštećenja.