The role of microRNAs in development and function of regulatory T cells : lessons for a better understanding of microRNA biology
- MicroRNAs (miRNAs) have emerged as critical posttranscriptional regulators of the immune system, including function and development of regulatory T (Treg) cells. Although this critical role has been firmly demonstrated through genetic models, key mechanisms of miRNA function in vivo remain elusive. Here, we review the role of miRNAs in Treg cell development and function. In particular, we focus on the question what the study of miRNAs in this context reveals about miRNA biology in general, including context-dependent function and the role of individual targets vs. complex co-targeting networks. In addition, we highlight potential technical pitfalls and state-of-the-art approaches to improve the mechanistic understanding of miRNA biology in a physiological context.
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| Author: | Heike Kunze-SchumacherORCiDGND, Andreas KruegerORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-562030 |
| DOI: | https://doi.org/10.3389/fimmu.2020.02185 |
| ISSN: | 1664-3224 |
| Parent Title (English): | Frontiers in immunology |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/09/09 |
| Date of first Publication: | 2020/09/09 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/10/08 |
| Tag: | gene regulation T-cell receptor; Treg cell; miRNA; regulatory T cell; thymus |
| Volume: | 11 |
| Issue: | art. 2185 |
| Page Number: | 8 |
| First Page: | 1 |
| Last Page: | 8 |
| Note: | © 2020 Kunze-Schumacher and Krueger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| HeBIS-PPN: | 472527959 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Open-Access-Publikationsfonds: | Medizin |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
