Radon exposure - therapeutic effect and cancer risk

Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exp
Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.
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Metadaten
Author:Andreas Maier, Julia Wiedemann, Felicitas Rapp, Franziska Papenfuß, Franz Rödel, Stephanie Hehlgans, Udo Sebastian Gaipl, Gerhard Kraft, Claudia Fournier, Benjamin Frey
URN:urn:nbn:de:hebis:30:3-574854
DOI:http://dx.doi.org/10.3390/ijms22010316
ISSN:1422-0067
ISSN:1661-6596
Parent Title (English):International Journal of Molecular Sciences
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2020/12/30
Date of first Publication:2020/12/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/01/06
Tag:anti-inflammatory effects; changes immune activation; clinical studies; low doses; osteoimmunological changes; radon therapy; α-particles
Volume:22.2021
Issue:Article 316
Pagenumber:39
HeBIS PPN:477683975
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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