Carrow I. Wells, Hassan Al-Ali, David M. Andrews, Christopher R. M. Asquith, Alison D. Axtman, Ivan Đikić, Daniel Ebner, Peter Ettmayer, Christian Fischer, Mathias Frederiksen, Robert E. Futrell, Nathanael S. Gray, Stephanie B. Hatch, Stefan Knapp, Ulrich Lücking, Michael Michaelides, Caitlin E. Mills, Susanne Müller, Dafydd R. Owen, Alfredo Picado, Kumar S. Saikatendu, Martin Schröder, Alexandra Stolz, Mariana Tellechea, Brandon J. Turunen, Santiago Vilar, Jinhua Wang, William J. Zuercher, Timothy M. Willson, David H. Drewry
- We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
Metadaten| Author: | Carrow I. WellsORCiD, Hassan Al-AliORCiD, David M. AndrewsORCiD, Christopher R. M. AsquithORCiD, Alison D. AxtmanORCiD, Ivan ĐikićORCiDGND, Daniel EbnerORCiD, Peter EttmayerORCiDGND, Christian Fischer, Mathias FrederiksenORCiD, Robert E. Futrell, Nathanael S. GrayORCiDGND, Stephanie B. HatchORCiD, Stefan KnappORCiD, Ulrich Lücking, Michael Michaelides, Caitlin E. MillsORCiD, Susanne MüllerORCiD, Dafydd R. OwenORCiD, Alfredo PicadoORCiD, Kumar S. Saikatendu, Martin SchröderORCiDGND, Alexandra StolzORCiDGND, Mariana TellecheaORCiD, Brandon J. Turunen, Santiago Vilar, Jinhua Wang, William J. ZuercherORCiD, Timothy M. WillsonORCiD, David H. DrewryORCiD |
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| URN: | urn:nbn:de:hebis:30:3-576979 |
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| DOI: | https://doi.org/10.3390/ijms22020566 |
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| ISSN: | 1422-0067 |
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| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/33429995 |
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| Parent Title (English): | International Journal of Molecular Sciences |
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| Publisher: | MDPI |
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| Place of publication: | Basel |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2021/01/08 |
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| Date of first Publication: | 2021/01/08 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2021/01/21 |
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| Tag: | KCGS; chemogenomic set; drug discovery; druggable genome; kinase inhibitor; phenotypic screening; protein kinase; small molecules; understudied kinase |
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| Volume: | 22 |
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| Issue: | Article 566 |
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| Page Number: | 18 |
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| HeBIS-PPN: | 477684076 |
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| Institutes: | Medizin / Medizin |
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| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - Namensnennung 4.0 |
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