The plasmodium export element revisited
We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.
| Author: | Jan Alexander Hiß, Jude Marek Przyborski, Florian Schwarte, Klaus Lingelbach, Gisbert Schneider |
|---|---|
| URN: | urn:nbn:de:hebis:30-57797 |
| DOI: | http://dx.doi.org/10.1371/journal.pone.0001560 |
| ISSN: | 1932-6203 |
| Parent Title (English): | PLoS one |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 25.09.2008 |
| Year of first Publication: | 2008 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Source: | PLoS ONE 3(2): e1560. doi:10.1371/journal.pone.0001560 |
| HeBIS PPN: | 205844839 |
| Institutes: | Biowissenschaften |
| Dewey Decimal Classification: | 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Sondersammelgebiets-Volltexte Biologie | |
| Note: | © 2008 Hiss et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
