Posttranslational modifications in conserved transcription factors: a survey of the TALE-homeodomain superclass in human and mouse

Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence informati
Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence information into the production of proteins or functional RNAs. TFs of the same family are often highly conserved in evolution, raising the question of how proteins with seemingly similar structure and DNA-binding properties can exert physiologically distinct functions or respond to context-specific extracellular cues. A good example is the TALE superclass of homeodomain-containing proteins. All TALE-homeodomain proteins share a characteristic, 63-amino acid long homeodomain and bind to similar sequence motifs. Yet, they frequently fulfill non-redundant functions even in domains of co-expression and are subject to regulation by different signaling pathways. Here we provide an overview of posttranslational modifications that are associated with murine and human TALE-homeodomain proteins and discuss their possible importance for the biology of these TFs.
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Metadaten
Author:Marina Reichlmeir, Lena Elias, Dorothea Schulte
URN:urn:nbn:de:hebis:30:3-610751
DOI:http://dx.doi.org/10.3389/fcell.2021.648765
ISSN:2296-634X
Parent Title (English):Frontiers in cell and developmental biology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2021/03/09
Date of first Publication:2021/03/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/06/22
Tag: PBX; MEIS; PTM; homeodomain protein; protein phosphorylation
Volume:9
Issue:art. 366
Pagenumber:10
First Page:1
Last Page:10
HeBIS PPN:481547517
Institutes:Medizin
Dewey Decimal Classification:570 Biowissenschaften; Biologie
610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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