Case report : symptomatic chronic granulomatous disease in the newborn

  • Chronic granulomatous disease (CGD) is a primary immunodeficiency, which is diagnosed in most patients between one and three years of age. Here we report on a boy who presented at birth with extensive skin lesions and lymphadenopathy which were caused by CGD. An analysis of the literature revealed 24 patients with CGD who became symptomatic during the first six weeks of life. Although pulmonary complications and skin lesions due to infection were the leading symptoms, clinical features were extremely heterogenous. As follow-up was not well specified in most patients, the long-term prognosis of children with very early onset of CGD remains unknown.
Metadaten
Author:Milica Miladinovic, Boris WittekindtORCiDGND, Sebastian Fischer, Elise GradhandORCiDGND, Steffen Kunzmann, Stefanie-Yvonne Zimmermann, Shahrzad BakhtiarGND, Thomas KlingebielORCiDGND, Rolf Schlösser, Thomas LehrnbecherORCiDGND
URN:urn:nbn:de:hebis:30:3-611303
DOI:https://doi.org/10.3389/fimmu.2021.663883
ISSN:1664-3224
Parent Title (English):Frontiers in immunology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2021/03/29
Date of first Publication:2021/03/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/06/09
Tag:chronic granulomatous disease; early onset; neonate; outcome; symptoms
Volume:12
Issue:art. 663883
Page Number:9
First Page:1
Last Page:9
HeBIS-PPN:481541225
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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