Flow electrosynthesis for efficient O-trifluoromethylation of electron-deficient phenols
- A sustainable strategy for O-trifluoromethylation of electron-deficient phenols by combining electrochemical synthesis with flow technology is presented. The reaction is optimized by screening experiments to establish a fast and efficient flow protocol. Simultaneous anodic oxidation of Langlois reagent and the phenols in a micro flow cell leads to direct preparation of trifluoromethyl ethers in yields up to 90%. This one-step protocol is tolerant of several functional groups, shows good regioselectivity and works without any chemical oxidants and catalysts by using electrical current as an inexpensive and sustainable reagent.
Download full text files
Additional Services
| Author: | Johannes BerndORCiD, Andreas TerfortORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-790701 |
| DOI: | https://doi.org/10.1016/j.elecom.2023.107545 |
| ISSN: | 1388-2481 |
| Parent Title (English): | Electrochemistry communications |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2023/08/09 |
| Date of first Publication: | 2023/07/28 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/10/23 |
| Tag: | Flow chemistry; Green chemistry; Organic electrochemistry; Trifluoromethoxy groups; Trifluoromethylation |
| Volume: | 154 |
| Issue: | 107545 |
| Article Number: | 107545 |
| Page Number: | 5 |
| HeBIS-PPN: | 516383043 |
| Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
