Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart
- Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular matrix components and various other factors shaping the microenvironment of the heart. In silico analysis of intercellular communication based on single-cell RNA sequencing revealed that fibroblasts are the source of the majority of outgoing signals to other cell types. This observation suggests that fibroblasts play key roles in orchestrating cellular interactions that maintain organ homeostasis but that can also contribute to disease states. Here, we will review the current knowledge of fibroblast interactions in the healthy, diseased, and aging heart. We focus on the interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes.
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| Author: | Luka NicinORCiD, Julian Uwe Gabriel WagnerORCiDGND, Guillermo LuxánORCiD, Stefanie DimmelerORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-752132 |
| DOI: | https://doi.org/10.1002/1873-3468.14234 |
| ISSN: | 1873-3468 |
| Parent Title (English): | FEBS letters |
| Publisher: | Wiley |
| Place of publication: | Chichester |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/11/17 |
| Date of first Publication: | 2021/11/17 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/08/24 |
| Tag: | aging; cardiomyocytes; cardiovascular disease; electrical coupling; endothelial cells; exosomes; fibroblasts; heart; immune cells; paracrine signaling |
| Volume: | 596 |
| Issue: | 5 |
| Page Number: | 17 |
| First Page: | 638 |
| Last Page: | 654 |
| HeBIS-PPN: | 512570787 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
