Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

Grundmann, Florian; Dill, Veronika; Dowling, Andrea; Thanwisai, Aunchalee; Bode, Edna; Chantratita, Narisara; ffrench-Constant, Richard; Bode, Helge Björn

doi:10.3762/bjoc.8.85

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Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

Florian Grundmann, Veronika Dill, Andrea Dowling, Aunchalee Thanwisai, Edna Bode, Narisara Chantratita, Richard ffrench-Constant, Helge Björn Bode

Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of these natural oxazoles. In order to confirm their structure, they were synthesized, which also allowed tests of their bioactivity. Additionally, the bioactivities of the synthesis intermediates were also investigated revealing interesting biological activities for several compounds despite their overall simple structures.

Metadaten
Verfasserangaben:	Florian Grundmann, Veronika Dill, Andrea Dowling, Aunchalee Thanwisai, Edna Bode ORCiD GND, Narisara Chantratita, Richard ffrench-Constant, Helge Björn Bode ORCiD GND
URN:	urn:nbn:de:hebis:30:3-288799
DOI:	https://doi.org/10.3762/bjoc.8.85
ISSN:	1860-5397
Pubmed-Id:	https://pubmed.ncbi.nlm.nih.gov/23015823
Titel des übergeordneten Werkes (Englisch):	Beilstein journal of organic chemistry
Verlag:	Frankfurt, Main
Verlagsort:	Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Dokumentart:	Wissenschaftlicher Artikel
Sprache:	Englisch
Datum der Veröffentlichung (online):	18.05.2012
Datum der Erstveröffentlichung:	18.05.2012
Veröffentlichende Institution:	Universitätsbibliothek Johann Christian Senckenberg
Datum der Freischaltung:	14.02.2013
Freies Schlagwort / Tag:	Pseudomonas; insecticidal activity; labradorin; oxazole; secondary metabolite
Jahrgang:	8
Seitenzahl:	4
Erste Seite:	749
Letzte Seite:	752
Bemerkung:	Copyright © 2012, Grundmann et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
HeBIS-PPN:	331513404
Institute:	Biowissenschaften / Biowissenschaften
DDC-Klassifikation:	5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:	Universitätspublikationen
	Sammlung Biologie / Sondersammelgebiets-Volltexte
Lizenz (Deutsch):	Creative Commons - Namensnennung 2.0

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Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

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