isiKnock: in silico knockouts in biochemical pathways
- isiKnock is a new software that automatically conducts in silico knockouts for mathematical models of biochemical pathways. The software allows for the prediction of the behavior of biological systems after single or multiple knockout. The implemented algorithm applies transition invariants and the novel concept of Manatee invariants. A knockout matrix visualizes the results. The tool enables the analysis of dependencies, for example, in signal flows from the receptor activation to the cell response at steady state.
| Author: | Jennifer Scheidel, Heiko GieseORCiD, Börje Schweizer, Leonie Katharina AmsteinORCiDGND, Jörg AckermannORCiDGND, Ina KochORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-724777 |
| DOI: | https://doi.org/10.1101/313858 |
| Parent Title (English): | bioRxiv |
| Document Type: | Preprint |
| Language: | English |
| Date of Publication (online): | 2018/05/04 |
| Date of first Publication: | 2018/05/04 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/09/04 |
| Issue: | 313858 |
| Page Number: | 3 |
| HeBIS-PPN: | 511534396 |
| Institutes: | Informatik und Mathematik / Informatik |
| Dewey Decimal Classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
