The KINETIC phase 2 randomised controlled trial of oral pamapimod-pioglitazone in non-critically ill COVID-19 inpatients
- The combination of pamapimod and pioglitazone (KIN001) has a synergetic antiviral, anti-inflammatory, and antifibrotic activity, which may prevent evolution toward COVID-19-associated severe respiratory failure. In a randomized, placebo-controlled, double-blind, phase 2, multicenter trial, 128 non-critically ill hospitalized patients with confirmed COVID-19 were treated with KIN001 or a placebo for 28 days. The proportion of patients alive and free of oxygen or respiratory support at the end of the therapy was lower than anticipated but not different in the two groups (KIN001 n = 19, 29%, placebo n = 21, 33%). 85 participants had at least one adverse event, with no difference in the number and distribution of events between the two groups. The clinical trial was stopped for futility, mainly due to a lower-than-expected incidence of the primary endpoint. KIN001 was safe and well-tolerated but had no significant effect on clinical outcome.
Author: | Thierry FumeauxORCiD, Claudia Berger, Alexander Bausch, Matthew Wright, Urosh Vilimanovich, Ivan Soldatovic, Maria J. G. T. VehreschildORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-791477 |
DOI: | https://doi.org/10.1016/j.isci.2023.108038 |
ISSN: | 2589-0042 |
Parent Title (English): | iScience |
Publisher: | Elsevier |
Place of publication: | Amsterdam [u.a.] |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/10/14 |
Date of first Publication: | 2023/09/27 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/02/05 |
Volume: | 26 |
Issue: | 108038 |
Article Number: | 108038 |
Page Number: | 10 |
First Page: | 1 |
Last Page: | 9 |
HeBIS-PPN: | 519273087 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |