Bianca Schuhmacher, Benjamin Rengstl, Claudia Döring, Julia Bein, Sebastian Newrzela, Uta Brunnberg, Hans Michael Kvasnicka, Martine Vornanen, Ralf Küppers, Martin-Leo Hansmann, Sylvia Hartmann
- Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent lymphoma, but can transform into diffuse large B cell lymphoma (DLBCL), showing a more aggressive clinical behavior. Little is known about these cases on the molecular level. Therefore, the aim of the present study was to characterize DLBCL transformed from NLPHL (LP-DLBCL) by gene expression profiling (GEP). GEP revealed an inflammatory signature pinpointing to a specific host response. In a coculture model resembling this host response, DEV tumor cells showed an impaired growth behavior. Mechanisms involved in the reduced tumor cell proliferation included a downregulation of MYC and its target genes. Lack of MYC expression was also confirmed in 12/16 LP-DLBCL by immunohistochemistry. Furthermore, CD274/PD-L1 was upregulated in DEV tumor cells after coculture with T cells or monocytes and its expression was validated in 12/19 cases of LP-DLBCL. Thereby, our data provide new insights into the pathogenesis of LP-DLBCL and an explanation for the relatively low tumor cell content. Moreover, the findings suggest that treatment of these patients with immune checkpoint inhibitors may enhance an already ongoing host response in these patients.
MetadatenVerfasserangaben: | Bianca SchuhmacherGND, Benjamin Rengstl, Claudia DöringGND, Julia Bein, Sebastian Newrzela, Uta BrunnbergGND, Hans Michael KvasnickaORCiD, Martine Vornanen, Ralf KüppersORCiDGND, Martin-Leo HansmannGND, Sylvia HartmannORCiDGND |
---|
URN: | urn:nbn:de:hebis:30:3-458348 |
---|
DOI: | https://doi.org/10.18632/oncotarget.12363 |
---|
ISSN: | 1949-2553 |
---|
Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/27708232 |
---|
Titel des übergeordneten Werkes (Englisch): | Oncotarget |
---|
Verlag: | Impact Journals LLC |
---|
Verlagsort: | [S.l.] |
---|
Dokumentart: | Wissenschaftlicher Artikel |
---|
Sprache: | Englisch |
---|
Jahr der Fertigstellung: | 2016 |
---|
Datum der Erstveröffentlichung: | 30.09.2016 |
---|
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
---|
Datum der Freischaltung: | 13.03.2018 |
---|
Freies Schlagwort / Tag: | T cell/histiocyte rich large B cell lymphoma; diffuse large B cell lymphoma; gene expression profiling; host response; nodular lymphocyte predominant Hodgkin lymphoma |
---|
Jahrgang: | 7 |
---|
Ausgabe / Heft: | 44 |
---|
Seitenzahl: | 14 |
---|
Erste Seite: | 72197 |
---|
Letzte Seite: | 72210 |
---|
Bemerkung: | All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License. |
---|
HeBIS-PPN: | 432108777 |
---|
Institute: | Medizin / Medizin |
---|
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Sammlungen: | Universitätspublikationen |
---|
Lizenz (Deutsch): | Creative Commons - Namensnennung 3.0 |
---|