Caroline M. Wernicke, Thomas G. P. Grunewald, Hendrik Juenger, Selim Kuçi, Zyrafete Kuçi, Ulrike Köhl, Ingo Mueller, Michaela Döring, Christina Peters, Anita Lawitschka, Hans-Jochem Kolb, Peter Bader, Stefan Burdach, Irene Teichert- von Lüttichau
- Severe acute graft versus host disease (GvHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. Human mesenchymal stromal cells (MSCs) play an important role in endogenous tissue repair and possess strong immune-modulatory properties making them a promising tool for the treatment of steroid-refractory GvHD. To date, a few reports exist on the use of MSCs in treatment of GvHD in children indicating that children tend to respond better than adults, albeit with heterogeneous results. We here present a review of the literature and the clinical course of two instructive pediatric patients with acute steroid-refractory GvHD after haploidentical stem cell transplantation, which exemplify the beneficial effects of third-party transplanted MSCs in treatment of acute steroid-refractory GvHD. Moreover, we provide a meta-analysis of clinical studies addressing the outcome of patients with steroid-refractory GvHD and treatment with MSCs in adults and in children (n = 183; 122 adults, 61 children). Our meta-analysis demonstrates that the overall response-rate is high (73.8%) and confirms, for the first time, that children indeed respond better to treatment of GvHD with MSCs than adults (complete response 57.4% vs. 45.1%, respectively). These data emphasize the significance of this therapeutic approach especially in children and indicate that future prospective studies are needed to assess the reasons for the observed differential response-rates in pediatric and adult patients. Additional file 1: MSCs expansion and release criteria.his file contains a detailed description of the MSCs expansion and release criteria for Case A and Case B.
MetadatenVerfasserangaben: | Caroline M. Wernicke, Thomas G. P. Grunewald, Hendrik Juenger, Selim KuçiORCiDGND, Zyrafete KuçiGND, Ulrike KöhlORCiDGND, Ingo Mueller, Michaela DöringORCiDGND, Christina Peters, Anita Lawitschka, Hans-Jochem Kolb, Peter BaderORCiDGND, Stefan Burdach, Irene Teichert- von Lüttichau |
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URN: | urn:nbn:de:hebis:30-112629 |
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DOI: | https://doi.org/10.1186/1755-7682-4-27 |
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Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/21843360 |
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Titel des übergeordneten Werkes (Englisch): | International archives of medicine |
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Verlag: | BioMed Central |
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Verlagsort: | London |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 09.09.2011 |
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Datum der Erstveröffentlichung: | 15.08.2011 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 09.09.2011 |
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Jahrgang: | 4 |
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Ausgabe / Heft: | Art. 27 |
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Seitenzahl: | 9 |
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Erste Seite: | 1 |
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Letzte Seite: | 9 |
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Bemerkung: | © 2011 Wernicke et al. ; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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HeBIS-PPN: | 27458591X |
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Institute: | Medizin / Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - Namensnennung 2.0 |
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