Wie kleine Amyloid-β-Peptide zum großen Problem im Gehirn werden können
- The formation of amyloid-β oligomers plays a key role in the onset of Alzheimer’s disease. We investigated the aggregation of amyloid-β oligomers by mass spectrometry and ion mobility spectrometry, revealing those structural properties, which lead to the formation of mature fibrils. We can show that the arrangement of the first oligomers is crucial for the topology of the resulting species, leading to the formation of non-toxic aggregates or fibrils.
Download full text files
Additional Services
| Author: | Rene ZanglORCiD, Nina MorgnerORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-695474 |
| DOI: | https://doi.org/10.1007/s12268-021-1678-1 |
| ISSN: | 1868-6249 |
| Parent Title (German): | Biospektrum |
| Publisher: | Spektrum |
| Place of publication: | Heidelberg |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2021/11/24 |
| Date of first Publication: | 2021/11/24 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/08/17 |
| Volume: | 27 |
| Issue: | 7 |
| Page Number: | 4 |
| First Page: | 705 |
| Last Page: | 708 |
| Note: | Open Access funding enabled and organized by Projekt DEAL. |
| HeBIS-PPN: | 511904223 |
| Institutes: | Biochemie, Chemie und Pharmazie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
