Sila-Pharmaka, 31. Mitt. [1]. Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon
Sila-Pharmaca, 31 th communication [1]. Synthesis, structure, and pharmacological properties of diphenyl(2-piperidinoethoxymethyl)silanol and its carbon analogue
- In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
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| Author: | Reinhold TackeORCiDGND, Hartwig Lange, William S. SheldrickGND, Günter Lambrecht, Ulrich MoserGND, Ernst MutschlerGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-719732 |
| DOI: | https://doi.org/10.1515/znb-1983-0615 |
| ISSN: | 1865-7117 |
| ISSN: | 0932-0776 |
| Parent Title (German): | Zeitschrift für Naturforschung, B |
| Publisher: | Verlag der Zeitschrift für Naturforschung |
| Place of publication: | Tübingen |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2014/06/02 |
| Year of first Publication: | 1983 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/01/13 |
| Tag: | Antimuscarinic and Papaverine-Like Activity; Crystal and Molecular Structure; Sila-Substitution |
| Volume: | 38.1983 |
| Issue: | 6 |
| Page Number: | 9 |
| First Page: | 738 |
| Last Page: | 746 |
| Institutes: | Biochemie, Chemie und Pharmazie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
