Rupert Tscheliessnig, Martin Zörnig, Eva M. Herzig, Katharina Maria Lückerath, Jens Altrichter, Kristina Kemter, Adnana-Nicoleta Paunel-Görgülü, Tim Tobias Lögters, Joachim Windolf, Silvia Pabisch, Jindrich Cinatl, Holger Rabenau, Alois Jungbauer, Peter Müller-Buschbaum, Martin Scholz, Joachim Koch
- The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.
