Autoimmune keratitis in mycobacterium tuberculosis
- Purpose: To report a case of autoimmune keratitis in a patient with mycobacterium tuberculosis (MBT). Methods: An 84-year-old male with pulmonary tuberculosis (TB) was admitted with chronic, non-healing bilateral ulcerations of the inferior peripheral cornea associated with stromal and subconjunctival nodules. Results: Clinical examination revealed circumscribed peripheral corneal ulceration with whitish nodules in adjacent stromal and subconjunctival tissue. Microbiological cultures of the corneal tissue were negative for MBT and other microbial pathogens; however, enzyme-linked immunosorbent assay (ELISA) of blood and corneal samples showed significantly elevated levels of IgM and IgA against MBT. In addition to systemic anti-tuberculosis therapy, the patient was treated topically with Polyspectran® eye drops, Dexamethasone eye drops, and Bepanthen® ointment, for 2 weeks. Both eyes showed dramatic improvement after 2 weeks. Conclusion: The present report demonstrates that MBT is able to initiate delayed autoimmune response within the corneal tissue during an intensive phase of anti-tuberculosis treatment.
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| Author: | Parviz Rafiezadeh, Ingo SchmackORCiDGND, Mehdi ShajariGND, Thomas KohnenORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-774345 |
| DOI: | https://doi.org/10.1016/j.joco.2018.03.001 |
| ISSN: | 2452-2325 |
| Parent Title (English): | Journal of current ophthalmology |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2018/11/29 |
| Date of first Publication: | 2018/05/18 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/10/31 |
| Tag: | Autoimmune response; Ocular tuberculosis; Phlyctenule; Scrofulous keratitis |
| Volume: | 30 |
| Issue: | 4 |
| Page Number: | 3 |
| First Page: | 381 |
| Last Page: | 383 |
| HeBIS-PPN: | 515067342 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
