Assay of ethanol and congener alcohols in serum and beverages by headspace gas chromatography/mass spectrometry
- The analysis of ethanol and of its congeners in blood plays an important role in forensic cases, especially when allegations are made that alcohol has been consumed after an accident. In alcoholic beverages, congener alcohols are by-products and are generated during fermentation. The assay of these compounds in serum samples and beverages has been previously performed using headspace-gas chromatography-flame ionization detection methods (HS-GC-FID). As an alternative, a robust headspace-gas chromatography-mass spectrometry (HS-GC-MS) procedure was developed and validated, which has the following advantages: - Simultaneous determination of ethanol, congener alcohols and other endogenous substances. - Reduction of matrix interference by increasing selectivity and specificity. - Clear separation of the positional isomers 3-methyl-1-butanol and 2-methyl-1-butanol.
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| Author: | Cora WunderORCiDGND, Werner Pogoda, Alexander PaulkeGND, Stefan W. TönnesORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-780426 |
| DOI: | https://doi.org/10.1016/j.mex.2021.101563 |
| ISSN: | 2215-0161 |
| Parent Title (English): | MethodsX |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam [u.a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/10/29 |
| Date of first Publication: | 2021/10/29 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/04/24 |
| Tag: | 1-propanol; Alcohol; Methanol; Method validation; Post-offence drinking |
| Volume: | 8 |
| Article Number: | 101563 |
| Page Number: | 7 |
| First Page: | 1 |
| Last Page: | 7 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
