Generation and physiological roles of linear ubiquitin chains

  • Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology. Ubiquitination usually involves the addition of ubiquitin chains to target protein molecules, and these may be of eight different types, seven of which involve the linkage of one of the seven internal lysine (K) residues in one ubiquitin molecule to the carboxy-terminal diglycine of the next. In the eighth, the so-called linear ubiquitin chains, the linkage is between the amino-terminal amino group of methionine on a ubiquitin that is conjugated with a target protein and the carboxy-terminal carboxy group of the incoming ubiquitin. Physiological roles are well established for K48-linked chains, which are essential for signaling proteasomal degradation of proteins, and for K63-linked chains, which play a part in recruitment of DNA repair enzymes, cell signaling and endocytosis. We focus here on linear ubiquitin chains, how they are assembled, and how three different avenues of research have indicated physiological roles for linear ubiquitination in innate and adaptive immunity and suppression of inflammation.

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Metadaten
Author:Henning Walczak, Kazuhiro Iwai, Ivan ĐikićORCiDGND
URN:urn:nbn:de:hebis:30:3-242193
DOI:https://doi.org/doi:10.1186/1741-7007-10-23
ISSN:1741-7007
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/22420778
Parent Title (English):BMC biology
Publisher:Springer
Place of publication:Berlin ; Heidelberg
Document Type:Article
Language:English
Date of Publication (online):2012/03/15
Date of first Publication:2012/03/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/03/22
Volume:10
Issue:23
Page Number:6
HeBIS-PPN:303189991
Institutes:Biochemie, Chemie und Pharmazie / Biochemie und Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sammlung Biologie / Biologische Hochschulschriften (Goethe-Universität)
Licence (German):License LogoCreative Commons - Namensnennung 3.0