Synthesis of szentiamide : a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
- The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
Author: | Friederike I. Nollmann, Andrea Dowling, Marcel Kaiser, Klaus Deckmann, Sabine GröschORCiDGND, Richard French-Constant, Helge Björn BodeORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-252060 |
DOI: | https://doi.org/10.3762/bjoc.8.60 |
ISSN: | 1860-5397 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/22563351 |
Parent Title (English): | Beilstein journal of organic chemistry |
Publisher: | Hindawi |
Place of publication: | New York, NY |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2012/04/11 |
Date of first Publication: | 2012/04/11 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2012/06/27 |
Tag: | Xenorhabdus; cyclic depsipeptide; esterification; natural product; szentiamide |
Volume: | 8 |
Page Number: | 6 |
First Page: | 528 |
Last Page: | 533 |
HeBIS-PPN: | 357454197 |
Institutes: | Biowissenschaften / Biowissenschaften |
Medizin / Medizin | |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 3.0 |