The matricellular functions of small leucine-rich proteoglycans (SLRPs)

  • The small leucine-rich proteoglycans (SLRPs) are biologically active components of the extracellular matrix (ECM), consisting of a protein core with leucine rich-repeat (LRR) motifs covalently linked to glycosaminoglycan (GAG) side chains. The diversity in composition resulting from the various combinations of protein cores substituted with one or more GAG chains along with their pericellular localization enables SLRPs to interact with a host of different cell surface receptors, cytokines, growth factors, and other ECM components, leading to modulation of cellular functions. SLRPs are capable of binding to: (i) different types of collagens, thereby regulating fibril assembly, organization, and degradation; (ii) Toll-like receptors (TLRs), complement C1q, and tumor necrosis factor-alpha (TNFα), regulating innate immunity and inflammation; (iii) epidermal growth factor receptor (EGF-R), insulin-like growth factor receptor (IGF-IR), and c-Met, influencing cellular proliferation, survival, adhesion, migration, tumor growth and metastasis as well as synthesis of other ECM components; (iv) low-density lipoprotein receptor-related protein (LRP-1) and TGF-β, modulating cytokine activity and fibrogenesis; and (v) growth factors such as bone morphogenic protein (BMP-4) and Wnt-I-induced secreted protein-1 (WISP-1), controlling cell proliferation and differentiation. Thus, the ability of SLRPs, as ECM components, to directly or indirectly regulate cell-matrix crosstalk, resulting in the modulation of various biological processes, aptly qualifies these compounds as matricellular proteins.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Metadaten
Author:Rosetta Merline, Roland Schäfer, Liliana SchäferORCiD
URN:urn:nbn:de:hebis:30:3-263898
DOI:https://doi.org/10.1007/s12079-009-0066-2
ISSN:1873-9601
ISSN:1873-961X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/19809894
Parent Title (English):Journal of cell communication and signaling
Publisher:Springer Netherlands
Place of publication:Dordrecht
Document Type:Article
Language:English
Date of Publication (online):2012/09/21
Date of first Publication:2009/10/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/09/21
Tag:Biglycan; Decorin; Fibrosis; Inflammation; Innate immunity; Lumican
Volume:3
Issue:3-4
Page Number:13
First Page:323
Last Page:335
Note:
Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
HeBIS-PPN:358181224
Institutes:Medizin / Medizin
Fachübergreifende Einrichtungen / Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0