Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study

  • Background: Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims to fill that gap. Methods: Serum concentrations of leptin, the soluble leptin receptor (sOB-R) and the free leptin index (FLI) were obtained in healthy control subjects (n=19), acutely ill individuals (n=14) and recovered patients with AN (n=15). Serum Zn concentrations noted in previous research data were also incorporated for all groups. Results: Leptin, FLI and Zn concentrations were higher in recovered subjects with AN when compared with acutely ill AN patients. Remitted patients showed higher sOB-R concentrations but no difference in FLI compared with the control group. Leptin and FLI were lower in the acutely ill patients compared with the control subjects, who showed no differences in Zn concentrations. Zn concentrations were not correlated with leptin, sOB-R or FLI concentrations in any of the three investigated subgroups. Conclusions: The present investigation does not entirely support an association between Zn, Leptin and FLI concentrations in subjects with AN, possibly due to limited statistical power. Further research and replication of the present findings related to the interaction between leptin and Zn is warranted. However, with respect to serum leptin levels the data of the present investigation indicate that acutely ill and remitted patients with AN differ as regards serum leptin concentrations and FLI, which is in line with previous research.

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Metadaten
Author:Florian Daniel ZepfORCiDGND, Idil SungurtekinORCiD, Franziska Glass, Linda Elstrodt, Dirk Peetz, Gudrun HinterederORCiD, Jürgen Kratzsch, Caroline Sarah Biskup, Fritz PoustkaGND, Lars Wöckel
URN:urn:nbn:de:hebis:30:3-266825
DOI:https://doi.org/10.3402/fnr.v56i0.10941
ISSN:1654-661X
ISSN:1654-6628
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/22393314
Parent Title (English):Food & nutrition research
Publisher:Co-Action Publishing
Place of publication:Häggeby [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2012/03/01
Date of first Publication:2012/03/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/10/16
Tag:anorexia nervosa; free leptin index (FLI); leptin, leptin receptor (sOB-R); zinc
Volume:56
Issue:10941
Page Number:8
Note:
Copyright © 2012 F.D. Zepf et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS-PPN:358291836
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0