Drug therapy of primary biliary diseases: classical and modern strategies

Definition: Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both cholestatic liver diseases. A common feature of these disorders is the accumulation of bile acids in the liver and blood, pres
Definition: Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both cholestatic liver diseases. A common feature of these disorders is the accumulation of bile acids in the liver and blood, presumably because of decreased biliary secretion and reduced bile flow. 
Etiology: Etiology and pathogenesis of PBC and PSC are still unknown. PBC is considered to be an autoimmune disease. Immunological mechanisms may also be involved in PSC since there is an association with ulcerative colitis and autoantibodies can be detected. Furthermore, genetic factors seem to play an important role in both diseases. 
Therapy: Since the pathogenesis of both diseases is unclear, there is no definite causal treatment. However, ursodeoxycholic acid (UDCA) was shown to be highly effective. Other drugs which can be used alone or in combination with UDCA are promising and might further improve the outcome of the diseases. 
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Author:Julia Schlichting, Ulrich Leuschner
URN:urn:nbn:de:hebis:30:3-264261
DOI:http://dx.doi.org/10.1111/j.1582-4934.2001.tb00144.x
ISSN:1582-4934
ISSN:1582-1838
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=12067457
Parent Title (English):Journal of cellular and molecular medicine
Publisher:Wiley-Blackwell
Place of publication:Hoboken, NJ
Document Type:Article
Language:English
Date of Publication (online):2013/02/08
Year of first Publication:2001
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/02/08
Tag:biliary cirrhosis; immunosuppressants; primary biliary diseases; sclerosing cholangitis; ursodeoxycholic acid
Volume:5
Issue:1
Pagenumber:18
First Page:98
Last Page:115
HeBIS PPN:32768402X
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License Logo Veröffentlichungsvertrag für Publikationen

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