MicroRNAs in age-related diseases

Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RN
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, aging and disease. However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.
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Metadaten
Author:Stefanie Dimmeler, Pierluigi Nicotera
URN:urn:nbn:de:hebis:30:3-287890
DOI:http://dx.doi.org/10.1002/emmm.201201986
ISSN:1715-4684
ISSN:1757-4676
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=23339066
Parent Title (English):EMBO molecular medicine
Publisher:Wiley-VCH
Place of publication:Weinheim
Document Type:Article
Language:English
Date of Publication (online):2013/01/22
Date of first Publication:2013/01/22
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/02/07
Tag:cardiac; microRNA; neurodegeneration; senescence; vascular
Volume:5
Issue:2
Pagenumber:11
First Page:180
Last Page:190
Note:
Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO. This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
HeBIS PPN:33118821X
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0

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