Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients

Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation 
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients suffer from a long lasting defect of different arms of the immune system, which increases the risk for and deteriorates the prognosis of invasive fungal infections. In turn, advances in understanding these immune deficits have resulted in promising strategies to enhance or restore critical immune functions in allogeneic HSCT recipients. Potential approaches include the administration of granulocytes, since neutropenia is the single most important risk factor for invasive fungal infection, and preliminary clinical results suggest a benefit of adoptively transferred donor-derived antifungal T cells. In vitro data and animal studies demonstrate an antifungal effect of natural killer cells, but clinical data are lacking to date. This review summarizes and critically discusses the available data of immunotherapeutic strategies in allogeneic HSCT recipients suffering from invasive fungal infection.
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Metadaten
Author:Thomas Lehrnbecher, Stanislaw Schmidt, Lars Tramsen, Thomas Klingebiel
URN:urn:nbn:de:hebis:30:3-288925
DOI:http://dx.doi.org/10.3389/fonc.2013.00017
ISSN:2234-943X
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=23404543
Parent Title (English):Frontiers in oncology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2013/02/07
Date of first Publication:2013/02/07
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/02/14
Tag:T cell; allogeneic hematopoietic stem cell transplantation; granulocyte; immunotherapy; invasive fungal infection; natural killer cell
Volume:3
Issue:Article 17
Pagenumber:5
Note:
Copyright: © 2013 Lehrnbecher, Schmidt, Tramsen and Klingebiel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
HeBIS PPN:331602415
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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