IAPs on the move : role of inhibitors of apoptosis proteins in cell migration

Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecul
Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell shape and migration by controlling MAPK, NF-κB and Rho GTPases. IAPs directly control Rho GTPases, thus regulating cell shape and migration. For instance, XIAP and cIAP1 function as the direct E3 ubiquitin ligases of Rac1 and target it for proteasomal degradation. IAPs are differentially expressed in tumor cells and have been targeted by several cancer therapeutic drugs that are currently in clinical trials. Here, we summarize the current knowledge on the role of IAPs in the regulation of cell migration and discuss the possible implications of these observations in regulating tumor cell metastases. 
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Metadaten
Author:Tripat Kaur Oberoi-Khanuja, Arun Murali, Krishnaraj Rajalingam
URN:urn:nbn:de:hebis:30:3-293093
DOI:http://dx.doi.org/10.1038/cddis.2013.311
ISSN:2041-4889
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24008728
Parent Title (English):Cell death & disease
Publisher:Nature Publishing Group
Place of publication:London [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2013/09/05
Date of first Publication:2013/09/05
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/09/19
Tag:IAPs; XIAP; cIAP1 BIR; metastases; migration; tumour
Volume:4
Issue:784
Pagenumber:9
Note:
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
HeBIS PPN:35311457X
Institutes:Biochemie und Chemie
Medizin
Dewey Decimal Classification:570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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