Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia

  • Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the contribution of high gamma (>60 Hz) oscillations toward the pathophysiology is less established. To address this issue, we recorded magnetoencephalographic (MEG) data from 16 medicated patients with chronic schizophrenia and 16 controls during the perception of Mooney faces. MEG data were analysed in the 25–150 Hz frequency range. Patients showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces while responses to inverted stimuli were intact. Impaired processing of Mooney faces in schizophrenia patients was accompanied by a pronounced reduction in spectral power between 60–120 Hz (effect size: d = 1.26) which was correlated with disorganized symptoms (r = −0.72). Our findings demonstrate that deficits in high gamma-band oscillations as measured by MEG are a sensitive marker for aberrant cortical functioning in schizophrenia, suggesting an important aspect of the pathophysiology of the disorder.

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Author:Christine Grützner, Michael WibralORCiDGND, Limin Sun, Davide Rivolta, Wolf SingerORCiDGND, Konrad MaurerGND, Peter J. UhlhaasORCiDGND
URN:urn:nbn:de:hebis:30:3-298098
DOI:https://doi.org/10.3389/fnhum.2013.00088
ISSN:1662-5161
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23532620
Parent Title (English):Frontiers in human neuroscience
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2013/04/19
Date of first Publication:2013/03/26
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/04/19
Tag:MEG; gamma; perceptual organization; schizophrenia; synchrony
Volume:7
Issue:Article 88
Page Number:11
First Page:1
Last Page:11
Note:
Copyright © 2013 Grützner, Wibral, Sun, Rivolta, Singer, Maurer and Uhlhaas. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
HeBIS-PPN:33786909X
Institutes:Medizin / Medizin
Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0