Andreas M. Bucher, Carlo N. De Cecco, U. Joseph Schoepf, Felix G. Meinel, Aleksander W. Krazinski, James V. Spearman, Andrew D. McQuiston, Rui Wang, Judith Bucher, Thomas J. Vogl, Richard W. Katzberg
- The exact pathophysiology of contrast-induced nephropathy (CIN) is not fully clarified, yet the osmotic characteristics of contrast media (CM) have been a significant focus in many investigations of CIN. Osmotic effects of CM specific to the kidney include transient decreases in blood flow, filtration fraction, and glomerular filtration rate. Potentially significant secondary effects include an osmotically induced diuresis with a concomitant dehydrating effect. Clinical experiences that have compared the occurrence of CIN between the various classes of CM based on osmolality have suggested a much less than anticipated advantage, if any, with a lower osmolality. Recent animal experiments actually suggest that induction of a mild osmotic diuresis in association with iso-osmolar agents tends to offset potentially deleterious renal effects of high viscosity-mediated intratubular CM stagnation.
Metadaten| Author: | Andreas M. BucherGND, Carlo N. De CeccoORCiD, U. Joseph SchoepfORCiDGND, Felix G. Meinel, Aleksander W. Krazinski, James V. Spearman, Andrew D. McQuiston, Rui Wang, Judith Bucher, Thomas J. VoglORCiDGND, Richard W. Katzberg |
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| URN: | urn:nbn:de:hebis:30:3-369318 |
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| DOI: | https://doi.org/10.1155/2014/931413 |
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| ISSN: | 2314-6141 |
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| ISSN: | 2314-6133 |
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| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24800254 |
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| Parent Title (English): | BioMed research international |
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| Publisher: | Hindawi |
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| Place of publication: | New York [u.a.] |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2014/03/31 |
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| Date of first Publication: | 2014/03/31 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2015/02/10 |
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| Volume: | 2014 |
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| Issue: | Article ID 931413 |
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| Page Number: | 9 |
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| First Page: | 1 |
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| Last Page: | 8 |
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| Note: | Copyright © 2014 Andreas M. Bucher et al. This is an open access article distributed under the Creative Commons Attribution Licensehttp://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| HeBIS-PPN: | 368235769 |
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| Institutes: | Medizin / Medizin |
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| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - Namensnennung 3.0 |
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Creative Commons - Namensnennung 3.0