Solid-phase enrichment and analysis of electrophilic natural products
- In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude extracts via their reactivity against azide as a nucleophile followed by their subsequent enrichment using a cleavable azide-reactive resin (CARR). Using this approach, natural products carrying epoxides and α,β-unsaturated enones as well as several unknown compounds were identified in crude extracts from entomopathogenic Photorhabdus bacteria.
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| Author: | Frank Wesche, Yue He, Helge Björn BodeORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-442365 |
| DOI: | https://doi.org/10.3762/bjoc.13.43 |
| ISSN: | 1860-5397 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28382178 |
| Parent Title (English): | Beilstein journal of organic chemistry |
| Publisher: | Beilstein-Institut zur Förderung der Chemischen Wissenschaften |
| Place of publication: | Frankfurt, Main |
| Contributor(s): | S. Flitsch |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2017/06/22 |
| Date of first Publication: | 2017/03/02 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2017/06/22 |
| Tag: | Photorhabdus; azides; click chemistry; electrophilic natural products; enrichment; epoxides; glidobactin; stilbenes |
| Volume: | 13 |
| Issue: | 1 |
| Page Number: | 5 |
| First Page: | 405 |
| Last Page: | 409 |
| Note: | © 2017 Wesche et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) |
| HeBIS-PPN: | 424938170 |
| Institutes: | Biowissenschaften / Biowissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
