IL-18/IL-18BP and IL-22/IL-22BP : two interrelated couples with therapeutic potential
- Interleukin (IL)-18 and IL-22 are key components of cytokine networks that play a decisive role in (pathological) inflammation, host defense, and tissue regeneration. Tight regulation of cytokine-driven signaling, inflammation, and immunoactivation is supposed to enable nullification of a given deleterious trigger without mediating overwhelming collateral tissue damage or even activating a cancerous face of regeneration. In fact, feedback regulation by specific cytokine opponents is regarded as a major means by which the immune system is kept in balance. Herein, we shine a light on the interplay between IL-18 and IL-22 and their opponents IL-18 binding protein (IL-18BP) and IL-22BP in order to provide integrated information on their biology, pathophysiological significance, and prospect as targets and/or instruments of therapeutic intervention.
Author: | Heiko MühlORCiDGND, Malte BachmannGND |
---|---|
URN: | urn:nbn:de:hebis:30:3-508191 |
DOI: | https://doi.org/10.1016/j.cellsig.2019.109388 |
ISSN: | 1873-3913 |
ISSN: | 0898-6568 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31401146 |
Parent Title (English): | Cellular signalling |
Publisher: | Elsevier Science |
Place of publication: | Amsterdam [u. a.] |
Document Type: | Article |
Language: | English |
Year of Completion: | 2019 |
Date of first Publication: | 2019/08/08 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2019/08/26 |
Tag: | Interleukin-22 binding protein Cytokines; Inflammation; Interleukin-18; Interleukin-18 binding protein; Interleukin-22 |
Volume: | 63 |
Issue: | Art. 109388 |
Page Number: | 14 |
First Page: | 1 |
Last Page: | 14 |
Note: | © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/) |
HeBIS-PPN: | 454003609 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |