Johanna Gechter, Carolin Liebscher, Maximilian J. Geiger, André Wittmann, Florian Schlagenhauf, Ulrike Lüken, Hans-Ulrich Wittchen, Bettina Pfleiderer, Volker Arolt, Tilo Kircher, Benjamin Straube, Jürgen Deckert, Heike Weber, Martin J. Herrmann, Andreas Reif, Katharina Domschke, Andreas Ströhle
- Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli.
Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety.
Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC).
Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG.
MetadatenAuthor: | Johanna Gechter, Carolin Liebscher, Maximilian J. Geiger, André Wittmann, Florian Schlagenhauf, Ulrike Lüken, Hans-Ulrich WittchenORCiDGND, Bettina Pfleiderer, Volker AroltORCiDGND, Tilo KircherORCiDGND, Benjamin StraubeORCiDGND, Jürgen DeckertORCiDGND, Heike WeberORCiDGND, Martin J. Herrmann, Andreas ReifORCiDGND, Katharina Domschke, Andreas StröhleORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-517991 |
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DOI: | https://doi.org/10.1016/j.nicl.2019.102029 |
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ISSN: | 2213-1582 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31734525 |
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Parent Title (English): | NeuroImage: Clinical |
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Publisher: | Elsevier |
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Place of publication: | [Amsterdam u. a.] |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2019 |
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Date of first Publication: | 2019/10/21 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2019/12/02 |
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Tag: | Agoraphobia; Imaging genetics; NPSR1; Panic disorder; Westphal-Paradigm; fMRI |
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Volume: | 24 |
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Issue: | Art. 102029 |
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Page Number: | 8 |
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First Page: | 1 |
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Last Page: | 8 |
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Note: | © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). |
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HeBIS-PPN: | 459851233 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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