Zum Wirkungsmechanismus von 1-Nitroso-3-nitro-1-methyl-guanidin bei der Mutationsauslösung. 1. Wirkung von 1-Nitroso-3-nitro-1-methyl-guanidin auf die Matrizenaktivität der Polynucleotide bei der zellfreien Proteinsynthese
- The effect of NNMG on the template activities of different polynucleotides (polyuridylic acid, polycytidylic acid, polyadenylic acid and copolymer of adenylic and guanylic acid 5,5:1) and t-RNS was studied. The maximum inhibition of the messenger activity was found for poly-C, followed by poly-Α and poly-U. The acceptor activity of t-RNA was found to be inhibited by NNMG: maximum for proline, followed by serine, leucine, phenylalanine and lysine. The mechanism of these inhibitions was studied using NNMG radioactively labelled on the methyl group. Different amounts of radioactivity were found in the various polynucleotides and t-RNS.
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| Author: | Prakash ChandraGND, Adolf WackerGND, Roland SüßmuthGND, Franz LingensGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-748770 |
| DOI: | https://doi.org/10.1515/znb-1967-0511 |
| ISSN: | 1865-7117 |
| ISSN: | 0932-0776 |
| Parent Title (German): | Zeitschrift für Naturforschung, B |
| Publisher: | Verlag der Zeitschrift für Naturforschung |
| Place of publication: | Tübingen |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2014/06/02 |
| Year of first Publication: | 1967 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/09/25 |
| Volume: | 22 |
| Issue: | 5 |
| Page Number: | 6 |
| First Page: | 512 |
| Last Page: | 517 |
| HeBIS-PPN: | 513114459 |
| Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
