Domain organization of long autotransporter signal sequences
- Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane. They often possess exceptionally long N-terminal signal sequences. We analyzed 90 long signal sequences of bacterial autotransporters and members of the two-partner secretion pathway in silico and describe common domain organization found in 79 of these sequences. The domains are in agreement with previously published experimental data. Our algorithmic approach allows for the systematic identification of functionally different domains in long signal sequences. Keywords: bacterial autotransporter, sequence analysis, pattern, protein targeting, signal peptide, protein trafficking
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| Author: | Jan Alexander HißORCiDGND, Gisbert SchneiderORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30-82650 |
| Parent Title (German): | Bioinformatics and Biology Insights |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2010/10/19 |
| Year of first Publication: | 2009 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2010/10/19 |
| Tag: | bacterial autotransporter; pattern; protein targeting; protein trafficking; sequence analysis; signal peptide |
| Volume: | 3 |
| First Page: | 189 |
| Last Page: | 204 |
| Note: | This article is available from http://www.la-press.com. © the authors, licensee Libertas Academica Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction provided the original work is properly cited. |
| Source: | Bioinformatics and Biology Insights 2009:3, pp. 189–204 |
| HeBIS-PPN: | 229315801 |
| Institutes: | Biowissenschaften / Biowissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Sammlung Biologie / Sondersammelgebiets-Volltexte | |
| Licence (German): |  Deutsches Urheberrecht |
