Chronic myeloid leukemia: a model disease of the past, present and future
- Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
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| Author: | Valentina R. MinciacchiORCiD, Rahul KumarORCiD, Daniela Sandra KrauseORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-577036 |
| DOI: | https://doi.org/10.3390/cells10010117 |
| ISSN: | 2073-4409 |
| Parent Title (English): | Cells |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/01/10 |
| Date of first Publication: | 2021/01/10 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2021/01/12 |
| Tag: | bone marrow microenvironment; chronic myeloid leukemia; combination therapies; history; metabolism; targeted therapy |
| Volume: | 10 |
| Issue: | Article 117 |
| Page Number: | 23 |
| HeBIS-PPN: | 475950976 |
| Institutes: | Medizin / Medizin |
| Angeschlossene und kooperierende Institutionen / Georg-Speyer-Haus | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
