Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies
- The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder. Therefore, an optimized indication for SCT in AML first requires the determination of the individual relapse risk based on diverse chromosomal and molecular prognosis-defining aberrations. A broad panel of diagnostic methods is needed to allow such subclassification and prognostic stratification: cytomorphology, cytogenetics, molecular genetics, and immunophenotyping by multiparameter flow cytometry. These methods should not be seen as isolated techniques but as parts of an integral network with hierarchies and interactions. Examples for a poor risk constellation as a clear indication for allogeneic SCT are provided by anomalies of chromosome 7, complex aberrations, or FLT3-length mutations. In contrast, the favorable reciprocal translocations such as the t(15;17)/PML-RARA or t(8;21)/AML1-ETO are not indications for SCT in first remission due to the rather good prognosis after standard therapy. Further, the indication for SCT should include the results of minimal residual disease (MRD) diagnostics by polymerase chain reaction (PCR) or flow cytometry. New aspects for a safe and fast risk stratification as basis for an optimized indication for SCT in AML might be provided by novel technologies such as microarray-based gene expression profiling. Keywords: Acute Myeloid Leukemia (AML), Allogeneic Stem Cell Transplantation (SCT), Indication, Cytogenetics, Polymerase Chain Reaction (PCR)
Verfasserangaben: | Maite Hartwig, Axel R. Zander, Torsten Haferlach, Boris FehseORCiDGND, Nicolaus KrögerORCiDGND, Ulrike Bacher |
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URN: | urn:nbn:de:hebis:30-113040 |
DOI: | https://doi.org/10.3205/ctt2008-05-26-001-en |
ISSN: | 1867-416X |
ISSN: | 1866-8836 |
Titel des übergeordneten Werkes (Englisch): | Cellular Therapy and Transplantation |
Verlag: | Univ. Medical Center, Clinic for Stem Cell Transplantation, Center of Oncology |
Verlagsort: | Hamburg |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Veröffentlichung (online): | 24.08.2011 |
Jahr der Erstveröffentlichung: | 2008 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 24.08.2011 |
Freies Schlagwort / Tag: | Acute Myeloid Leukemia (AML); Allogeneic Stem Cell Transplantation (SCT); Cytogenetics; Indication; Polymerase Chain Reaction (PCR) |
Jahrgang: | 1 |
Ausgabe / Heft: | 1 |
Seitenzahl: | 7 |
Erste Seite: | 18 |
Letzte Seite: | 24 |
Bemerkung: | © The Authors. This article is provided under the following license: Creative Commons Attribution-Share Alike 2.0 Germany. Please cite this article as follows: Hartwig M, Zander AR, Haferlach T, Fehse B, Kröger N, Bacher U. Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies. Cell Ther Transplant. 2008;1:e.2008-05-26-001-en. doi:10.3205/ctt2008-05-26-001-en |
Quelle: | Cellular Therapy and Transplantation, Vol. 1, No. 1, 26 May 2008, p. 18-24, doi: 10.3205/ctt2008-05-26-001-en |
HeBIS-PPN: | 274605589 |
Institute: | Medizin / Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Lizenz (Deutsch): | Creative Commons - Namensnennung-Weitergabe unter gleichen Bedingungen |