Simon Bernatz, Daniel Monden, Florian Geßler, Tijana Radić, Elke Hattingen, Christian Senft, Volker Seifert, Michael Wilfried Ronellenfitsch, Karl Plate, Patrick Nikolaus Harter, Peter Baumgarten
- Higher grade meningiomas tend to recur. We aimed to evaluate protein levels of vascular endothelial growth factor (VEGF)-A with the VEGF-receptors 1-3 and the co-receptors Neuropilin (NRP)-1 and -2 in WHO grade II and III meningiomas to elucidate the rationale for targeted treatments. We investigated 232 specimens of 147 patients suffering from cranial meningioma, including recurrent tumors. Immunohistochemistry for VEGF-A, VEGFR-1-3, and NRP-1/-2 was performed on tissue micro arrays. We applied a semiquantitative score (staining intensity x frequency). VEGF-A, VEGFR-1-3, and NRP-1 were heterogeneously expressed. NRP-2 was mainly absent. We demonstrated a significant increase of VEGF-A levels on tumor cells in WHO grade III meningiomas (p = 0.0098). We found a positive correlation between expression levels of VEGF-A and VEGFR-1 on tumor cells and vessels (p < 0.0001). In addition, there was a positive correlation of VEGF-A and VEGFR-3 expression on tumor vessels (p = 0.0034). VEGFR-2 expression was positively associated with progression-free survival (p = 0.0340). VEGF-A on tumor cells was negatively correlated with overall survival (p = 0.0084). The VEGF-A-driven system of tumor angiogenesis might still present a suitable target for adjuvant therapy in malignant meningioma disease. However, its role in malignant tumor progression may not be as crucial as expected. The value of comprehensive testing of the ligand and all receptors prior to administration of anti-angiogenic therapy needs to be evaluated in clinical trials.
MetadatenVerfasserangaben: | Simon BernatzORCiDGND, Daniel MondenORCiD, Florian GeßlerORCiDGND, Tijana RadićGND, Elke HattingenORCiDGND, Christian SenftORCiDGND, Volker SeifertORCiD, Michael Wilfried RonellenfitschORCiDGND, Karl PlateGND, Patrick Nikolaus HarterORCiDGND, Peter BaumgartenORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-747298 |
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DOI: | https://doi.org/10.1007/s10735-020-09940-2 |
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ISSN: | 1567-2387 |
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Titel des übergeordneten Werkes (Englisch): | Journal of molecular histology |
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Verlag: | Springer Science + Business Media B.V. |
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Verlagsort: | Dordrecht [u.a.] |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 02.02.2021 |
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Datum der Erstveröffentlichung: | 02.02.2021 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 12.09.2023 |
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Freies Schlagwort / Tag: | Malignant meningioma; Meningioma; Neuropilin; VEGF; VEGF receptors |
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Jahrgang: | 52 |
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Ausgabe / Heft: | 2 |
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Seitenzahl: | 11 |
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Erste Seite: | 233 |
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Letzte Seite: | 243 |
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Bemerkung: | Open Access funding enabled and organized by Projekt DEAL. |
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HeBIS-PPN: | 513143084 |
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Institute: | Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - CC BY - Namensnennung 4.0 International |
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