TY  - JOUR
A1  - Zöller, Nadja Nicole
A1  - Valesky, Eva Maria
A1  - Hofmann, Matthias
A1  - Bereiter-Hahn, Jürgen
A1  - Bernd, August
A1  - Kaufmann, Roland
A1  - Meissner, Markus
A1  - Kippenberger, Stefan
T1  - Impact of different spa waters on inflammation parameters in human keratinocyte HaCaT cells
T2  - Annals of dermatology
N2  - Background: The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce.
Objective: In the present in vitro study, we compared the effect of culture media supplemented with (a) thermal spa waters (La Roche-Posay, Avène) and (b) two natural mineral drinking waters (Heppinger, Adelholzener) on physiological parameters in HaCaT keratinocytes.
Methods: The different medium preparations were investigated with regard to cell proliferation and cell damage. Moreover, the impact on inflammation parameters with and without ultraviolet B (UVB) irradiation was examined.
Results: Two popular thermal spring waters were found to suppress cell proliferation and cell damage. Moreover, these waters reversed the induction of interleukin-6, as measured using enzyme-linked immunosorbent assay and promoter transactivation, and the formation of reactive oxygen species after UVB stimulation. Of note, the two natural mineral waters, which are distributed as drinking waters, had some effect on the above-mentioned parameters but to a lesser extent.
Conclusion: In summary, our results show that spa waters, and particularly those derived from thermal springs, reduce parameters associated with inflammation. It seems likely that trace elements such as selenium and zinc are critical for the observed effects.
KW  - Inflammation
KW  - Interleukin-6
KW  - Keratinocytes
KW  - Reactive oxygen species
KW  - Spa water
KW  - Thermal spring water
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39236
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-392361
SN  - 2005-3894
SN  - 1013-9087
N1  - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 27
IS  - 6
SP  - 709
EP  - 714
CY  - Seoul
ER  -