TY  - JOUR
A1  - Clemen, Christoph Stephan
A1  - Marko, Marija
A1  - Strucksberg, Karl-Heinz
A1  - Behrens, Juliane
A1  - Wittig, Ilka
A1  - Gärtner, Linda
A1  - Winter, Lilli
A1  - Chevessier, Frederic
A1  - Matthias, Jan
A1  - Türk, Matthias
A1  - Tangavelou, Karthikeyan
A1  - Schütz, Johanna
A1  - Arhzaouy, Khalid
A1  - Klopffleisch, Karsten
A1  - Hanisch, Franz-Georg
A1  - Rottbauer, Wolfgang
A1  - Blümcke, Ingmar
A1  - Just, Steffen
A1  - Eichinger, Ludwig
A1  - Hofmann, Andreas
A1  - Schröder, Rolf
T1  - VCP and PSMF1: antagonistic regulators of proteasome activity
T2  - Biochemical and biophysical research communications
N2  - Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity.
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39382
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-393822
SN  - 0006-291X
N1  - © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 463
SP  - 1210
EP  - 1217
PB  - Elsevier
CY  - San Diego, Calif.
ER  -