TY  - JOUR
A1  - Knöchel, Christian
A1  - Alves, Gilberto Sousa
A1  - Friedrichs, Benedikt
A1  - Schneider, Barbara
A1  - Schmidt-Rechau, Anna
A1  - Wenzlera, Sofia
A1  - Schneider, Angelina
A1  - Prvulovic, David
A1  - Carvalho, André Férrer
A1  - Oertel-Knöchel, Viola
T1  - Treatment-resistant late-life depression: challenges and perspectives
T2  - Current Neuropharmacology
N2  - The current Review article provides a narrative review about the neurobiological underpinnings and treatment of treatment resistant late-life depression (TRLLD). The manuscript focuses on therapeutic targets of late-life depression, which include pharmacological, psychological, biophysical and exercise treatment approaches. Therefore, we summarize available evidences on that kind of therapies for patients suffering from late-life depression. The search for evidences of therapeutic options of late-life depression were done using searching websites as “pubmed”, and using the searching terms “depression”, “late-life depression”, “treatment”, “biophysical therapy”, “exercise therapy”, “pharmacological therapy” and “psychological therapy”. To the end, we summarize and discuss current data, providing some directions for further research.
Treatment recommendations for elderly depressive patients favour a multimodal approach, containing psychological, pharmacological and secondary biophysical therapeutic options. Particularly, a combination of psychotherapy and antidepressant medication reflects the best therapeutic option. However, mostly accepted and used is the pharmacological treatment although evidence suggests that the drug therapy is not as effective as it is in younger depressive patients. Further studies employing larger samples and longer follow-up periods are necessary and may focus on comparability of study designs and involve novel approaches to establish the validity and reliability of multimodal treatment programs.
KW  - antidepressants
KW  - electroconvulsive therapy
KW  - late-life depression
KW  - psychotherapy
KW  - review
KW  - treatment-resistant
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41290
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-412900
SN  - 1570-159X
N1  - This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
VL  - 13
IS  - 5
SP  - 577
EP  - 591
PB  - Bentham Science Publ.
CY  - Hilversum [u.a.]
ER  -