TY  - JOUR
A1  - Hohenforst-Schmidt, Wolfgang
A1  - Zarogoulidis, Paul
A1  - Stopek, Joshua
A1  - Kosmidis, Efstratios
A1  - Vogl, Thomas J.
A1  - Linsmeier, Bernd
A1  - Tsakiridis, Kosmas
A1  - Lampaki, Sofia
A1  - Lazaridis, George
A1  - Mpakas, Andreas
A1  - Browning, Robert
A1  - Papaiwannou, Antonis
A1  - Drevelegas, Antonis
A1  - Baka, Sofia
A1  - Karavasilis, Vasilis
A1  - Mpoukovinas, Ioannis
A1  - Turner, J. Francis
A1  - Zarogoulidis, Konstantinos
A1  - Brachmann, Johannes
T1  - Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol : future concept for local treatment in lung cancer
T2  - Journal of cancer
N2  - Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (106) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm3 the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.
KW  - lung cancer
KW  - intratumoral
KW  - lipiodol
KW  - cisplatin
KW  - microwave ablation
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/36494
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-364943
SN  - 1837-9664
N1  - © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
VL  - 6
IS  - 3
SP  - 218
EP  - 226
PB  - Ivyspring Internat. Publ.
CY  - Wyoming, NSW
ER  -