TY - JOUR A1 - Raulf, Anika A1 - Spahn, Christoph Klaus A1 - Zessin, Patrick A1 - Finan, Kieran A1 - Bernhardt, Stefan A1 - Heckel, Alexander A1 - Heilemann, Mike T1 - Click chemistry facilitates direct labelling and super-resolution imaging of nucleic acids and proteins T2 - RSC Advances N2 - We demonstrate high-density labelling of cellular DNA and RNA using click chemistry and perform confocal and super-resolution microscopy. We visualize the crescent and ring-like structure of densely packed RNA in nucleoli. We further demonstrate click chemistry with unnatural amino acids for super-resolution imaging of outer-membrane proteins of E. coli. Y1 - 2014 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45016 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-450166 SN - 2046-2069 N1 - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. VL - 4 IS - 57 SP - 30462 EP - 30466 PB - RSC Publishing CY - London ER -