TY  - JOUR
A1  - Lehnert, Elisa
A1  - Tampé, Robert
T1  - Structure and dynamics of antigenic peptides in complex with TAP
T2  - Frontiers in immunology
N2  - The transporter associated with antigen processing (TAP) selectively translocates antigenic peptides into the endoplasmic reticulum. Loading onto major histocompatibility complex class I molecules and proofreading of these bound epitopes are orchestrated within the macromolecular peptide-loading complex, which assembles on TAP. This heterodimeric ABC-binding cassette (ABC) transport complex is therefore a major component in the adaptive immune response against virally or malignantly transformed cells. Its pivotal role predestines TAP as a target for infectious diseases and malignant disorders. The development of therapies or drugs therefore requires a detailed comprehension of structure and function of this ABC transporter, but our knowledge about various aspects is still insufficient. This review highlights recent achievements on the structure and dynamics of antigenic peptides in complex with TAP. Understanding the binding mode of antigenic peptides in the TAP complex will crucially impact rational design of inhibitors, drug development, or vaccination strategies.
KW  - ABC transporter
KW  - antigen processing
KW  - ligand binding
KW  - membrane proteins
KW  - peptide-loading complex
KW  - substrate-binding site
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45168
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-451682
SN  - 1664-3224
N1  - Copyright © 2017 Lehnert and Tampé. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 8
IS  - Art. 10
SP  - 1
EP  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -