Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol : future concept for local treatment in lung cancer

  • Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (106) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm3 the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

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Author:Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Joshua Stopek, Efstratios Kosmidis, Thomas J. VoglORCiDGND, Bernd Linsmeier, Kosmas Tsakiridis, Sofia Lampaki, George Lazaridis, Andreas Mpakas, Robert Browning, Antonis Papaiwannou, Antonis Drevelegas, Sofia Baka, Vasilis Karavasilis, Ioannis Mpoukovinas, J. Francis Turner, Konstantinos Zarogoulidis, Johannes BrachmannORCiDGND
URN:urn:nbn:de:hebis:30:3-364943
DOI:https://doi.org/10.7150/jca.10970
ISSN:1837-9664
Parent Title (English):Journal of cancer
Publisher:Ivyspring Internat. Publ.
Place of publication:Wyoming, NSW
Document Type:Article
Language:English
Date of Publication (online):2015/01/06
Date of first Publication:2015/01/06
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2015/01/20
Tag:cisplatin; intratumoral; lipiodol; lung cancer; microwave ablation
Volume:6
Issue:3
Page Number:9
First Page:218
Last Page:226
Note:
© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
HeBIS-PPN:367504944
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0