Preoperative interleukin-22 values add valuable information for outcome prediction following orthotopic liver transplantation: a preliminary study

BACKGROUND: Recent findings support the idea that interleukin (IL)-22 serum levels are related to disease severity in end-stage liver disease. Existing scoring systems--Model for End-Stage Liver Disease (MELD), Survival 
BACKGROUND: Recent findings support the idea that interleukin (IL)-22 serum levels are related to disease severity in end-stage liver disease. Existing scoring systems--Model for End-Stage Liver Disease (MELD), Survival Outcomes Following Liver Transplantation (SOFT) and Pre-allocation-SOFT (P-SOFT)--are well-established in appraising survival rates with or without liver transplantation. We tested the hypothesis that IL-22 serum levels at transplantation date correlate with survival and potentially have value as a predictive factor for survival.
MATERIAL AND METHODS: MELD, SOFT, and P-SOFT scores were calculated to estimate post-transplantation survival. Serum levels of IL-22, IL-6, IL-10, C-reactive protein (CRP), and procalcitonin (PCT) were collected prior to transplantation in 41 patients. Outcomes were assessed at 3 months, 1 year, and 3 years after transplantation.
RESULTS: IL-22 significantly correlated with MELD, P-SOFT, and SOFT scores (Rs 0.35, 0.63, 0.56 respectively, p<0.05) and with the discrimination in post-transplantation survival. IL-6 showed a heterogeneous pattern (Rs 0.40, 0.63, 0.57, respectively, p<0.05); CRP and PCT did not correlate. We therefore added IL-22 serum values to existing scoring systems in a generalized linear model (GLM), resulting in a significantly improved outcome prediction in 58% of the cases for both the P-SOFT (p<0.01) and SOFT scores (p<0.001).
CONCLUSIONS: Further studies are needed to address the concept that IL-22 serum values at the time of transplantation provide valuable information about survival rates following orthotopic liver transplantation.
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Author:Tobias M. Bingold, Lara Just, Colleen Cuca, Kai Zacharowski, Christian Mönch, Heiko Mühl, Heimo Wissing, Gordon Pipa, Peter Rosenberger, Wolf Otto Bechstein, Patrick Paulus, Bertram Scheller
URN:urn:nbn:de:hebis:30:3-344173
DOI:http://dx.doi.org/10.12659/AOT.890977
ISSN:1425-9524
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25300347
Parent Title (English):Annals of transplantation
Publisher:Pressmed
Place of publication:Warsaw
Document Type:Article
Language:English
Date of Publication (online):2016/11/11
Date of first Publication:2014/10/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/11/11
Volume:19
Pagenumber:10
First Page:503
Last Page:512
Note:
This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
HeBIS PPN:424804840
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0

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