VCP and PSMF1: antagonistic regulators of proteasome activity

Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardi
Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity.
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Author:Christoph S. Clemen, Marija Marko, Karl-Heinz Strucksberg, Juliane Behrens, Ilka Wittig, Linda Gärtner, Lilli Winter, Frederic Chevessier, Jan Matthias, Matthias Türk, Karthikeyan Tangavelou, Johanna Schütz, Khalid Arhzaouy, Karsten Klopffleisch, Franz-Georg Hanisch, Wolfgang Rottbauer, Ingmar Blümcke, Steffen Just, Ludwig Eichinger, Andreas Hofmann, Rolf Schröder
URN:urn:nbn:de:hebis:30:3-393822
DOI:http://dx.doi.org/10.1016/j.bbrc.2015.06.086
ISSN:0006-291X
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=26086101
Parent Title (English):Biochemical and biophysical research communications
Publisher:Elsevier
Place of publication:San Diego, Calif.
Document Type:Article
Language:English
Date of Publication (online):2015/08/07
Date of first Publication:2015/06/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/05/30
Volume:463
Pagenumber:8
First Page:1210
Last Page:1217
Note:
© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
HeBIS PPN:427808464
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0

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