Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan
- Aging of biological systems is accompanied by degeneration of mitochondrial functions. Different pathways are active to counteract the processes which lead to mitochondrial dysfunction. Mitochondrial dynamics, the fission and fusion of mitochondria, is one of these quality control pathways. Mitophagy, the controlled degradation of mitochondria, is another one. Here we show that these pathways are linked. A double deletion mutant of Saccharomyces cerevisiae in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated, contain wild-type like filamentous mitochondria, but are characterized by impaired respiration, an increased sensitivity to different stressors, increased mitochondrial protein carbonylation, and a decrease in mitophagy and replicative lifespan. These data show that a balanced mitochondrial dynamics and not a filamentous mitochondrial morphotype per se is the key for a long lifespan and demonstrate a cross-talk between two different mitochondrial quality control pathways.
Author: | Dominik Bernhardt, Matthias Müller, Andreas ReichertORCiDGND, Heinz D. OsiewaczORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-393854 |
DOI: | https://doi.org/10.1038/srep07885 |
ISSN: | 2045-2322 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/25601284 |
Parent Title (English): | Scientific reports, 5.2015, 7885 |
Publisher: | Nature Publishing Group |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2015/01/20 |
Date of first Publication: | 2015/01/20 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2016/02/03 |
Volume: | 5 |
Issue: | 7885 |
Page Number: | 9 |
First Page: | 1 |
Last Page: | 9 |
Note: | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-nd/4.0/ |
HeBIS-PPN: | 378134302 |
Institutes: | Biowissenschaften / Biowissenschaften |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |