Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk

Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A2 and prostaglandin (PG)E2, generated from arachidonic acid (AA) by the activity of cy
Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A2 and prostaglandin (PG)E2, generated from arachidonic acid (AA) by the activity of cyclooxygenase (COX)-1], granule content, including ADP and growth factors, chemokines, proteases and Wnt proteins. Moreover, activated platelets shed different vesicles, such as microparticles (MPs) and exosomes (rich in genetic material such as mRNAs and miRNAs). These platelet-derived products induce several phenotypic changes in cancer cells which confer high metastatic capacity. A central event involves an aberrant expression of COX-2 which influences cell-cycle progression and contribute to the acquisition of a cell migratory phenotype through the induction of epithelial mesenchymal transition genes and down-regulation of E-cadherin expression. The identification of novel molecular determinants involved in the cross-talk between platelets and cancer cells has led to identify novel targets for anti-cancer drug development.
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Metadaten
Author:Melania Dovizio, Sara Alberti, Angela Sacco, Paloma Guillem-Llobat, Simone Schiavone, Thorsten Jürgen Maier, Dieter Steinhilber, Paola Patrignani
URN:urn:nbn:de:hebis:30:3-403383
DOI:http://dx.doi.org/10.1042/BST20140322
Parent Title (English):Biochemical Society Transactions
Publisher:Portland Press
Place of publication:London
Document Type:Article
Language:English
Year of Completion:2015
Year of first Publication:2015
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/06/02
Tag:colon cancer cells; cyclooxygenase 1 (COX-1); cyclooxygenase 2 (COX-2); epithelial mesenchymal transition; metastasis; platelets
Volume:43
Issue:4
Pagenumber:8
First Page:707
Last Page:714
HeBIS PPN:427808596
Institutes:Medizin
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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